Promethazine with Codeine Oral Answer is made up of codeine, a Agenda V managed compound. As an opioid, Promethazine with Codeine Oral Alternative exposes users into the challenges of dependancy, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE (9)], which can lead to overdose and death [seeOVERDOSAGE (ten)]. Reserve Promethazine with Codeine Oral